GALLERY
Professor Swanson presentation at the 2024 Telluride Science Town Talks series
Lasso work featured on the cover of the Journal of Physical Chemistry, B. This work highlights how combining the strengths of AI and human intuition was successful in identifying a transferable lasso to tadpole reaction coordinate.
Lasso work featured on the cover of JACS. This work reveals that lasso peptides indeed fold to their native right-handed structures and that de novo folding is very entropically unfavorable, but that lasso folding can be stabilized via sequence, chemical modifications, or reaction conditions.
In collaboration with Professor Andrew Roberts, Swanson Group developed computational tools to simulate and better understand abiotic lasso peptide folding.
Lasso Wars: The Folding Menace – created by Gabriel da Hora
Mycolactone work featured on the cover of Toxins. This work reveals why only one of the two isoforms is cytotoxic.
Graphic from mycolactone cover story. Through a combination of preferential membrane interactions increasing the local substrate reservoir and distinct interactions with the Sec61 translocon, only Mycolactone B blocks protein translocation, killing host cells in the neglected tropical skin disease Buruli ulcer.
Graphic from mycolactone cover story. Through a combination of preferential membrane interactions increasing the local substrate reservoir and distinct interactions with the Sec61 translocon, only Mycolactone B blocks protein translocation, killing host cells in the neglected tropical skin disease Buruli ulcer.
Work with our friends in the Henne Group (UT Southwestern) explains how previously orphaned protein TG-associated lipid droplet protein 1 (Tld1) targets a subpopulation of TG-rich lipid droplets and seemingly protects them from lipolysis.
Polarizable simulations reveal triacylglycerols shift charge distribution, making Drude the most accurate force field for lipid droplet simulations, while standard C36 is a close second that performs well at the lipid droplet/water/protein interface.
